Martin-Luther-Universität Halle-Wittenberg

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Forschungsschwerpunkte

  • Einfluss von Vitamin D auf den Lipidstoffwechsel, kardiovaskuläre Risikofaktoren und die Atherogenese
  • Funktionelle Bedeutung von Peroxisomenproliferator-aktivierten Rezeptoren (PPARs) in der Regulation des Lipid- und Energiestoffwechsels
  • Biofunktionalität von spezifischen Aminosäuren und pflanzlichen Proteinen
  • Einfluss von oxidierten Fetten und des Redoxstatus auf die Lipogenese

Relevante Publikationen zu den Forschungsschwerpunkten

Einfluss von Vitamin D auf den Lipidstoffwechsel, kardiovaskuläre Risikofaktoren und die Atherogenese

  • Hesse M, Brandsch C, König B, Stangl GI (2010) Einfluss von Vitamin D auf die transkriptionelle Regulation des Lipidstoffwechsels von humanen Leberhepatomzellen. Proc. Germ. Nutr. Soc. 14, 62


Funktionelle Bedeutung von Peroxisomenproliferator-aktivierten Rezeptoren (PPARs) in der Regulation des Lipid- und Energiestoffwechsels

  • König B, Fischer S, Schlotte S, Wen G, Eder K, Stangl GI (2010) MCT1/CD147 is up-regulated by natural and synthetic PPARa agonists in liver. Mol. Food Nutr. Res. 54, 1248-1256
  • König B, Rauer C, Rosenbaum S, Brandsch C, Eder K, Stangl GI (2009) Fasting up-regulates PPARa target genes in brain and influences pituitary hormone expression in a PPARa dependent manner. PPAR Res. Epub
  • Gutgesell A, Wen G, König B, Koch A, Spielmann J, Stangl GI, Eder K, Ringseis R (2009) Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells. Biochim. Biophys. Acta 1790, 1206-1216
  • König B, Koch A, Spielmann J, Hilgenfeld C, Hirche F, Stangl GI, Eder K (2009) Activation of PPARa and PPARg reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1. Eur. J. Pharmacol. 605, 23-30
  • Gutgesell A, Ringseis R, Brandsch C, Stangl GI, Hirche F, Eder K (2009) Peroxisome proliferator-activated receptor a and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats. Metabolism 58, 226-232.
  • Gutgesell A, Ringseis R, Schmidt E, Brandsch C, Stangl GI, Eder K (2009) Downregulation of peroxisome proliferator-activated receptor alpha and its coactivators in liver and skeletal muscle mediates the metabolic adaptations during lactation in mice. J. Mol. Endocrinol. 43, 241-250.
  • König B, Koch A, Giggel K, Dordschbal B, Eder K, Stangl GI (2008) Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. Biochim. Biophys. Acta 1780, 899-904.
  • König B, Spielmann J, Haase K, Brandsch C, Kluge H, Stangl GI, Eder K (2008) Effects of fish oil and conjugated linoleic acids on expression of target genes of PPARa and sterol regulatory element-binding proteins in the liver of laying hens. Br. J. Nutr. 100, 355-363.
  • Koch A, König B, Stangl GI, Eder K (2008) PPARalpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis. Exp. Biol. Med. 233, 356-365.
  • Koch A, König B, Luci S, Stangl GI, Eder K (2007) Dietary oxidised fat up regulates the expression of organic cation transporters in liver and small intestine and alters carnitine concentrations in liver, muscle and plasma of rats. Br. J. Nutr. 98, 882-889.
  • König B, Koch A, Spielmann J, Hilgenfeld C, Stangl GI, Eder K (2007) Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2. Biochem. Pharmacol. 73, 574-585.
  • Luci S, König B, Giemsa B, Huber S, Hause G, Kluge H, Stangl GI, Eder K (2007) Feeding a deep-fried fat causes PPARalpha activation in the liver of pigs as a non-proliferating species. Br. J. Nutr. 97, 872-882.
  • König B, Kluge H, Haase K, Brandsch C, Stangl GI, Eder K (2007) Effects of clofibrate treatment in laying hens. Poult. Sci. 86, 1187-1195.
  • Luci S, Geissler S, König B, Koch A, Stangl GI, Hirche F, Eder K (2006) PPARalpha agonists up-regulate organic cation transporters in rat liver cells. Biochem. Biophys. Res. Commun. 350, 704-708

Biofunktionalität von spezifischen Aminosäuren und pflanzlichen Proteinen

  • Brandsch C, Kappis D, Weiße K, Stangl GI (2010) Effects of untreated and thermally treated lupin protein on plasma and liver lipids of rats fed a hypercholesterolemic high fat or high carbohydrate diet. Plant Foods Hum. Nutr. (Epub ahead of print)
  • Weiße K, Brandsch C, Eder K, Stangl GI (2010) Lupin protein isolate and cysteine-supplemented casein reduce calcification of atherosclerotic lesions in apoE-deficient mice. Br. J. Nutr. 103, 180-188.
  • Weiße K, Brandsch C, Zernsdorf B, Nkengfack Nembongwe GS, Hofmann K, Eder K, Stangl GI (2010) Lupin protein compared to casein lowers the LDL cholesterol:HDL-cholesterol-ratio of hypercholesterolemic adults. Eur. J. Nutr. 49, 65-71.
  • Bettzieche A, Brandsch C, Eder K, Stangl GI (2009) Lupin protein acts hypocholesterolemic and increases milk fat content in lactating rats by influencing the expression of genes involved in cholesterol homeostasis and triglyceride synthesis. Mol. Nutr. Food Res. 53, 1134-1142.
  • Spielmann J, Kluge H, Stangl GI, Eder K (2009) Hypolipidaemic effects of potato protein and fish protein in pigs. J. Anim. Physiol. Anim. Nutr. 93, 400-409
  • Spielmann J, Noatsch A, Brandsch C, Stangl GI, Eder K (2008) Effects of various dietary arginine and lysine concentrations on plasma and liver cholesterol concentrations in rats. Ann. Nutr. Metab. 53, 223-233.
  • Bettzieche A, Brandsch C, Schmidt M, Weisse K, Eder K, Stangl GI (2008) Protein isolates from different cultivars of blue lupin differently affect plasma lipoproteins of hypercholesterolemic rats. Biosci. Biotechnol. Biochem. 72, 3114-3121.
  • Bettzieche A, Brandsch C, Hirche F, Eder K, Stangl GI (2008) L-cysteine down-regulates SREBP-1c regulated lipogenic enzymes expression via glutathione in HepG2 cells.              Ann. Nutr. Metab. 52, 196-203.
  • Spielmann J, Stangl GI, Eder K (2008) Dietary pea protein stimulates bile acid excretion and lowers hepatic cholesterol concentration in rats. J. Anim. Physiol. Anim. Nutr. 92, 683-693.
  • Bettzieche A Brandsch C, Weiße K, Hirche F, Eder K, Stangl GI (2008) Lupin protein influences the expression of hepatic genes involved in fatty acid synthesis and triglyceride hydrolysis of adult rats. Br. J. Nutr. 99, 952-962.
  • Spielmann J, Shukla A, Brandsch C, Hirche F, Stangl GI, Eder K (2007) Dietary lupin protein lowers triglyceride concentrations in liver and plasma in rats by reducing hepatic gene expression of sterol regulatory element-binding protein-1c. Ann. Nutr. Metab. 51, 387-392.
  • Shukla A, Brandsch C, Bettzieche A, Hirche F, Stangl GI, Eder K (2007) Isoflavone-poor soy protein alters the lipid metabolism of rats by SREBP-mediated down-regulation of hepatic genes. J. Nutr. Biochem. 18, 313-321.
  • Stangl GI, Weisse K, Dinger C, Hirche F, Brandsch C, Eder K (2007) Homocysteine thiolactone-induced hyperhomocysteinemia does not alter concentrations of cholesterol and SREBP-2 target gene mRNAs in rats. Exp. Biol. Med. 232, 81-87.
  • Spielmann J, Shukla A, Brandsch C, Hirche F, Stangl GI, Eder K (2007) Dietary lupin protein lowers triglyceride concentrations in liver and plasma in rats by reducing hepatic gene expression of sterol regulatory element-binding protein-1c. Ann. Nutr. Metab. 51, 387-392
  • Hirche F, Schröder A, Knoth B, Stangl GI, Eder K (2006) Effect of dietary methionine on plasma and liver cholesterol concentrations in rats and expression of hepatic genes involved in cholesterol metabolism. Br. J. Nutr. 95, 879-888.


Einfluss von oxidierten Fetten und des Redoxstatus auf die Lipogenese

  • Brandsch C, Schmidt T, Weiße K, Behn D, Müller A, Stangl GI (2010) Glutathione depletion down-regulates hepatic lipogenesis in rats. Lipids Health Dis. (Epub ahead of print)
  • Müller AS, Klomann SD, Wolf NM, Schneider S, Schmidt R, Spielmann J, Stangl G, Eder K, Pallauf J (2008) Redox regulation of protein tyrosine phosphatase 1b by manipulation of dietary selenium affects the triglyceride concentration in rat liver. J. Nutr. 138, 2328-2336.
  • Koch A, König B, Spielmann J, Leitner A, Stangl GI, Eder K (2007) Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory element-binding protein-2 in rat liver. J. Nutr. 137, 2018-2023

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