Martin-Luther-Universität Halle-Wittenberg

Weiteres

Login für Redakteure





Research

Research interests

Mineral metabolism:

  • Regulation of FGF23 and Klotho and significance for health, aging, and age-related disease
  • Regulation of phosphate transport

Blood pressure and extracellular volume regulation

PI3K signaling

  • Physiological and pathophysiological role of insulin-dependent PI3 kinase signaling

Regulation and relevance of suicidal erythrocyte death

Regulation of electrogenic membrane transport

  • Regulation of ion channels and electrogenic secondary/tertiary active membrane transporters
  • Regulation and significance of store-operated calcium entry

Selected publications

Chen H, Fajol A, Hoene M, Zhang B, Schleicher ED, Lin Y, Calaminus C, Pichler BJ, Weigert C, Häring HU, Lang F, Foller M. PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome. Proc Natl Acad Sci U S A. 2016 May 7;113(20):5754-9.

Fajol A, Chen H, Umbach AT, Quarles LD, Lang F, Foller M. Enhanced FGF23 production in mice expressing PI3 kinase-insensitive GSK3 is normalized by β-blocker treatment. FASEB J 2016 Feb;30(2):994-1001

Fahkri H, Zhang B, Fajol A, Hernando N, Elvira B, Mannheim JG, Pichler B, Daniel C, Amann K, Hirao A, Haight J, Mak TW, Lang F, Foller M. Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phophate metabolism. Pflugers Arch 2015 Sep;467(9):1871-80

Umbach AT, Zhang B, Daniel C, Fajol A, Velic A, Hosseinzadeh Z, Bhavsar SK, Bock CT, Kandolf R, Pichler BJ, Amann K, Foller M, Lang F. JAK3 sensitivity of renal 25hydroxyvitamin D 1α-hydroxylase expression, 1,25(OH)2D3 formation, and phosphate metabolism. Kidney Int 2015 Apr;87(4):728-37

Luo D, Fajol A, Umbach A, Noegel AA, Laufer S, Lang F, Foller M. Influence of annexin A7 on insulin sensitivity of cellular glucose uptake. Pflugers Arch 2015 Apr;467(4):641-9

Lang E, Gatidis S, Freise NF, Bock H, Kubitz R, Lauermann C, Orth HM, Klindt C, Schuirer M, Keitel V, Reich M, Liu G, Schmidt S, Xu HC, Qadri SM, Herebian D, Mayatepek E, Gulbins E, Lang F, Häussinger D, Lang KS*, Foller M*, Lang PA*. Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology 2014 Jan;61(1):275-84 *shared senior-authorship

Lang F, Abed M, Lang E, Foller M. Oxidative stress and suicidal erythrocyte death. Antioxid Redox Signal 2014 Jul 1;21(1):138-53.

Foller M, Harris IS, Elia A, John R, Lang F, Kavanagh TJ, Mak TW. Functional significance of glutamate-cysteine ligase modifier (GCLM) for erythrocyte survival in vitro and in vivo. Cell Death Differ 2013 Oct;20(10):1350-8.

Almilaji A, Munoz C, Elvira B, Fajol A, Pakladok T, Honisch S, Shumilina E, Lang F, Foller M. AMP-activated protein kinase regulates hERG potassium channel. Pflugers Arch 2013 Nov;465(11):1573-82.

Andres-Mateos E, Brinkmeier H, Burks TN, Mejias R, Files DC, Steinberger M, Soleimani A, Marx R, Simmers JL, Lin B, Finanger Hedderick E, Marr TG, Lin BM, Hourde C, Leinwand LA, Kuhl D, Foller M, Vogelsang S, Hernandez-Diaz I, Vaughan DK, Alvarez de la Rosa D, Lang F, Cohn RD: Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO Mol Med 2013, 5(1):80-91.

Foller M, Hermann A, Gu S, Alesutan I, Qadri SM, Borst O, Schmidt EM, Schiele F, vom Hagen JM, Saft C, Schols L, Lerche H, Stournaras C, Storch A, Lang F: Chorein-sensitive polymerization of cortical actin and suicidal cell death in chorea-acanthocytosis. FASEB J 2012,
26(4):1526-1534.

Foller M, Jaumann M, Dettling J, Saxena A, Pakladok T, Munoz C, Ruth P, Sopjani M, Seebohm G, Ruttiger L, Knipper M, Lang F: AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation. FASEB J 2012, 26(10):4243-4253.

Salker MS, Christian M, Steel JH, Nautiyal J, Lavery S, Trew G, Webster Z, Al-Sabbagh M, Puchchakayala G, Foller M, Landles C, Sharkey AM, Quenby S, Aplin JD, Regan L, Lang F, Brosens JJ.  Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure Nat Med. 2011 Oct 16;17(11):1509-13.

Foller M, Kempe DS, Boini KM, Pathare G, Siraskar B, Capuano P, Alesutan I, Sopjani M, Stange G, Mohebbi N, Bhandaru M, Ackermann TF, Judenhofer MS, Pichler BJ, Biber J, Wagner CA, Lang F. PKB/SGK-resistant GSK3 enhances phosphaturia and calciuria. J Am Soc Nephrol 2011 May;22(5):873-80.

Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, Foller M, Lang F: Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney Int 2011, 80(1):61-67.

Foller M, Mahmud H, Qadri SM, Gu S, Braun M, Bobbala D, Hocher B, Lang F: Endothelin B receptor stimulation inhibits suicidal erythrocyte death. FASEB J 2010, 24(9):3351-3359.

Foller M, Sopjani M, Koka S, Gu S, Mahmud H, Wang K, Floride E, Schleicher E, Schulz E, Munzel T, Lang F: Regulation of erythrocyte survival by AMP-activated protein kinase. FASEB J 2009, 23(4):1072-1080.

Foller M, Feil S, Ghoreschi K, Koka S, Gerling A, Thunemann M, Hofmann F, Schuler B, Vogel J, Pichler B, Kasinathan RS, Nicolay JP, Huber SM, Lang F, Feil R. Anemia and splenomegaly in cGKI-deficient mice. Proc Natl Acad Sci U S A 2008 May 6;105(18):6771-6.

Zum Seitenanfang